Article
Mutant p53 proteins alter cancer cell secretome and tumour microenvironment: Involvement in cancer invasion and metastasis.
Cancer letters - 1 Jul 2016
Cordani Marco, Pacchiana Raffaella, Butera Giovanna, D'Orazi Gabriella, Scarpa Aldo, Donadelli Massimo
Abstract excerpt
An ever-increasing number of studies highlight the role of mutant p53 proteins in the alteration of cancer cell secretome and in the modification of tumour microenvironment, sustaining an invasive phenotype of cancer cell. The knowledge of the molecular mechanisms underlying the interplay between mutant p53 proteins and the microenvironment is becoming fundamental for the identification of both efficient...
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