Article
A Gradual Transition Toward Anaplasia in Wilms Tumor Through Tolerance to Genetic Damage.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Jan 2024
Uno Kaname, Rastegar Bahar, Jansson Caroline, Durand Geoffroy, Valind Anders, Chattopadhyay Subhayan, Bertolotti Alessia, Ciceri Sara, Spreafico Filippo, Collini Paola, Perotti Daniela, Mengelbier Linda Holmquist, Gisselsson David
Abstract excerpt
Patients with Wilms tumor (WT) in general have excellent survival, but the prognosis of patients belonging to the subgroup of WT with diffuse anaplasia (DA) is poor due to frequent resistance to chemotherapy. We hypothesized that DA WT cells might undergo changes, such as acquiring a persistent tolerance to DNA damage and copy number aberrations (CNAs), which could eventually lead to their resistance to...
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