Article
Molecular profiling reveals frequent gain of MYCN and anaplasia-specific loss of 4q and 14q in Wilms tumor.
Genes, chromosomes & cancer - 1 Dec 2011
Williams Richard D, Al-Saadi Reem, Natrajan Rachael, Mackay Alan, Chagtai Tasnim, Little Suzanne, Hing Sandra N, Fenwick Kerry, Ashworth Alan, Grundy Paul, Anderson James R, Dome Jeffrey S, Perlman Elizabeth J, Jones Chris, Pritchard-Jones Kathy
Abstract excerpt
Anaplasia in Wilms tumor, a distinctive histology characterized by abnormal mitoses, is associated with poor patient outcome. While anaplastic tumors frequently harbour TP53 mutations, little is otherwise known about their molecular biology. We have used array comparative genomic hybridization (aCGH) and cDNA microarray expression profiling to compare anaplastic and favorable histology Wilms tumors to determine...
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