Article
TP53 mutational status is a potential marker for risk stratification in Wilms tumour with diffuse anaplasia.
PloS one - 1 Jan 2014
Maschietto Mariana, Williams Richard D, Chagtai Tasnim, Popov Sergey D, Sebire Neil J, Vujanic Gordan, Perlman Elizabeth, Anderson James R, Grundy Paul, Dome Jeffrey S, Pritchard-Jones Kathy
Abstract excerpt
PURPOSE: The presence of diffuse anaplasia in Wilms tumours (DAWT) is associated with TP53 mutations and poor outcome. As patients receive intensified treatment, we sought to identify whether TP53 mutational status confers additional prognostic information. PATIENTS AND METHODS: We studied 40 patients with DAWT with anaplasia in the tissue from which DNA was extracted and analysed for TP53 mutations and 17p loss....
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