Article
MTOR gene variants are associated with severe COVID-19 outcomes: A multicenter study.
International immunopharmacology - 1 Dec 2023
Tosta Bruna Ramos, de Almeida Ingrid Marins, da Cruz Pena Laiane, Dos Santos Silva Hatilla, Reis-Goes Fabiane S, Silva Nívia N, Cruz João Victor Andrade, Dos Anjos Silva Mailane, de Araújo Jéssica Francisco, Rodrigues Juliana Lopes, Oliveira Gabriella, Figueiredo Ricardo Gassmann, Vaz Sara Nunes, Montaño-Castellón Iris, Santana Daniele, de Lima Beltrão Fabyan Esberard, Carneiro Valdirene Leão, Campos Gubio Soares, Brites Carlos, Fortuna Vitor, Figueiredo Camila Alexandrina, Trindade Soraya Castro, Ramos Helton Estrela, Costa Ryan Dos Santos
Abstract excerpt
BACKGROUND: The worst outcomes linked to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection have been attributed to the cytokine storm, which contributes significantly to the immunopathogenesis of the disease. The mammalian target of rapamycin (mTOR) pathway is essential for orchestrating innate immune cell defense including cytokine production and is dysregulated in severe Coronavirus Disease...
Topics
- Genetic Variation
- Humans
- COVID-19
- Patient Acuity
- Case-Control Studies
- Male
- Female
- Adult