Article
C9orf72 Intermediate Repeats Confer Genetic Risk for Severe COVID-19 Pneumonia Independently of Age.
International journal of molecular sciences - 29 Jun 2021
Zanella Isabella, Zacchi Eliana, Piva Simone, Filosto Massimiliano, Beligni Giada, Alaverdian Diana, Amitrano Sara, Fava Francesca, Baldassarri Margherita, Frullanti Elisa, Meloni Ilaria, Renieri Alessandra, Castelli Francesco, Quiros-Roldan Eugenia
Abstract excerpt
A cytokine storm, autoimmune features and dysfunctions of myeloid cells significantly contribute to severe coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Genetic background of the host seems to be partly responsible for severe phenotype and genes related to innate immune response seem critical host determinants. The C9orf72 gene has a...
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