Genetic signatures of AKT1 variants associated with worse COVID-19 outcomes - a multicentric observational study.

doi:10.3389/fimmu.2024.1422349

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Article

Genetic signatures of AKT1 variants associated with worse COVID-19 outcomes - a multicentric observational study.

Frontiers in immunology - 1 Jan 2024

de Almeida Ingrid Marins, Tosta Bruna Ramos, Pena Laiane da Cruz, Silva Hatilla Dos Santos, Reis-Goes Fabiane S, Silva Nívia N, Cruz João Victor Andrade, Silva Mailane Dos Anjos, de Araújo Jéssica Francisco, Rodrigues Juliana Lopes, Oliveira Gabriella, Figueiredo Ricardo Gassmann, Vaz Sara Nunes, Montaño-Castellón Iris, Santana Daniele, Torres Alex, Beltrão Fabyan Esberard de Lima, Carneiro Valdirene Leão, Campos Gubio Soares, Brites Carlos, Fortuna Vitor, Figueiredo Camila Alexandrina, Trindade Soraya Castro, Ramos Helton Estrela, Costa Ryan Dos Santos

Abstract excerpt

Introduction: The COVID-19, triggered by the SARS-CoV-2 virus, has varied clinical manifestations, ranging from mild cases to severe forms such as fatal pneumonia and acute respiratory distress syndrome (ARDS). Disease severity is influenced by an exacerbated immune response, characterized by high pro-inflammatory cytokine levels. Inhibition of AKT can potentially suppress pathological inflammation, cytokine...

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Identifiers

PMID: 39439795
DOI: 10.3389/fimmu.2024.1422349
PMCID: PMC11493623

Genes

AKT1
TNF

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