Article
An essential role of NF-kappaB in the "tumor-like" phenotype of arthritic synoviocytes.
Proceedings of the National Academy of Sciences of the United States of America - 14 Nov 2006
Li Xiangli, Makarov Sergei S
Abstract excerpt
A hallmark of rheumatoid arthritis is the formation of an aggressive, tumor-like structure called pannus that erodes the joint. A major cellular component of the pannus is the fibroblast-like synoviocyte (FLS), whose morphology strikingly resembles that of a transformed cell, but underlying mechanisms of this "transformation" are not known. Here, using animal models of rheumatoid arthritis, we show that arthritic...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.