Article
FGFR3 has tumor suppressor properties in cells with epithelial phenotype.
Molecular cancer - 31 Jul 2013
Lafitte Marie, Moranvillier Isabelle, Garcia Stéphane, Peuchant Evelyne, Iovanna Juan, Rousseau Benoit, Dubus Pierre, Guyonnet-Dupérat Véronique, Belleannée Geneviève, Ramos Jeanne, Bedel Aurélie, de Verneuil Hubert, Moreau-Gaudry François, Dabernat Sandrine
Abstract excerpt
BACKGROUND: Due to frequent mutations in certain cancers, FGFR3 gene is considered as an oncogene. However, in some normal tissues, FGFR3 can limit cell growth and promote cell differentiation. Thus, FGFR3 action appears paradoxical. RESULTS: FGFR3 expression was forced in pancreatic cell lines. The receptor exerted dual effects: it suppressed tumor growth in pancreatic epithelial-like cells and had oncogenic...
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