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Article

Association of homozygous variants of STING1 with outcome in human cervical cancer.

Cancer science - 1 Jan 2021

Lubbers Joyce M, Koopman Bart, de Klerk-Sluis Jessica M, van Rooij Nienke, Plat Annechien, Pijper Harry, Koopman Timco, van Hemel Bettien M, Hollema Harry, Wisman Bea, Nijman Hans W, de Bruyn Marco

Abstract excerpt

DNA-sensing receptor Cyclic GMP-AMP Synthase (cGAS) and its downstream signaling effector STimulator of INterferon Genes (STING) have gained significant interest in the field of tumor immunology, as a dysfunctional cGAS-STING pathway is associated with poor prognosis and worse response to immunotherapy. However, studies so far have not taken into account the polymorphic nature of the STING-encoding STING1 gene....

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Identifiers

PMID: 33040406
DOI: 10.1111/cas.14680
PMCID: PMC7780010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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