Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

TDP2 suppresses chromosomal translocations induced by DNA topoisomerase II during gene transcription

3 Aug 2017

Abstract excerpt

DNA double-strand breaks (DSBs) induced by abortive topoisomerase II (TOP2) activity are a potential source of genome instability and chromosome translocation. TOP2-induced DNA double-strand breaks are rejoined in part by tyrosyl-DNA phosphodiesterase 2 (TDP2)-dependent non-homologous end-joining (NHEJ), but whether this process suppresses or promotes TOP2-induced translocations is unclear. Here, we show that...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer therapeutics and mechanisms
Share to Lung Cancer Research Studies
Share to Polyomavirus and related diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 28794467
DOI: 10.1038/s41467-017-00307-y

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

TDP2 suppresses chromosomal translocations induced by DNA topoisomerase II during gene transcriptionPMID 28794467Read ↗

TDP2–Dependent Non-Homologous End-Joining Protects against Topoisomerase II–Induced DNA Breaks and Genome Instability in Cells and In VivoSemantic proximity Read ↗

TDP1 suppresses chromosomal translocations and cell death induced by abortive TOP1 activity during gene transcriptionSemantic proximity Read ↗

TDP2 promotes repair of topoisomerase I-mediated DNA damage in the absence of TDP1Semantic proximity Read ↗

Role of TDP2 in the repair of DNA damage induced by the radiomimetic drug BleomycinSemantic proximity Read ↗

Trapped topoisomerase II initiates formation of de novo duplications via the nonhomologous end-joining pathway in yeastSemantic proximity Read ↗

Trapped Topoisomerase II initiates formation of <i>de novo</i> duplications <i>via</i> the nonhomologous end-joining pathway in yeastSemantic proximity Read ↗

Mechanisms of leukemia translocationsSemantic proximity Read ↗

Topoisomerase 2β induces DNA breaks to regulate human papillomavirus replicationSemantic proximity Read ↗

Tyrosyl-DNA phosphodiesterase (Tdp1) participates in the repair of Top2-mediated DNA damage.Semantic proximity Read ↗

Reversal of DNA damage induced Topoisomerase 2 DNA-protein crosslinks by Tdp2.Semantic proximity Read ↗

TRF2 and Apollo Cooperate with Topoisomerase 2α to Protect Human Telomeres from Replicative DamageSemantic proximity Read ↗

Gross chromosomal rearrangements and genetic exchange between nonhomologous chromosomes following BRCA2 inactivation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.