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Article

Intrinsically disordered regions are not sufficient to direct the compartmental localization of nucleolar proteins in the nucleus.

PLoS biology - 1 Nov 2023

Lavering Emily D, Gandhamaneni Maunika, Weeks Daniel L

Abstract excerpt

The nucleolus is a non-membrane bound organelle central to ribosome biogenesis. The nucleolus contains a mix of proteins and RNA and has 3 known nucleolar compartments: the fibrillar center (FC), the dense fibrillar component (DFC), and the granular component (GC). The spatial organization of the nucleolus is influenced by the phase separation properties of nucleolar proteins, the presence of RNA, protein...

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Identifiers

PMID: 37943867
DOI: 10.1371/journal.pbio.3002378
PMCID: PMC10662738

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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