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Article

Ongoing U snRNP biogenesis is required for the integrity of Cajal bodies.

Molecular biology of the cell - 1 Jul 2006

Lemm Ira, Girard Cyrille, Kuhn Andreas N, Watkins Nicholas J, Schneider Marc, Bordonné Rémy, Lührmann Reinhard

Abstract excerpt

Cajal bodies (CBs) have been implicated in the nuclear phase of the biogenesis of spliceosomal U small nuclear ribonucleoproteins (U snRNPs). Here, we have investigated the distribution of the CB marker protein coilin, U snRNPs, and proteins present in C/D box small nucleolar (sno)RNPs in cells depleted of hTGS1, SMN, or PHAX. Knockdown of any of these three proteins by RNAi interferes with U snRNP maturation...

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Identifiers

PMID: 16687569
DOI: 10.1091/mbc.e06-03-0247
PMCID: PMC1483051

Genes

PHAX

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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