Article
The glycine arginine-rich domain of the RNA-binding protein nucleolin regulates its subcellular localization.
The EMBO journal - 18 Oct 2021
Doron-Mandel Ella, Koppel Indrek, Abraham Ofri, Rishal Ida, Smith Terika P, Buchanan Courtney N, Sahoo Pabitra K, Kadlec Jan, Oses-Prieto Juan A, Kawaguchi Riki, Alber Stefanie, Zahavi Eitan Erez, Di Matteo Pierluigi, Di Pizio Agostina, Song Didi-Andreas, Okladnikov Nataliya, Gordon Dalia, Ben-Dor Shifra, Haffner-Krausz Rebecca, Coppola Giovanni, Burlingame Alma L, Jungwirth Pavel, Twiss Jeffery L, Fainzilber Mike
Abstract excerpt
Nucleolin is a multifunctional RNA Binding Protein (RBP) with diverse subcellular localizations, including the nucleolus in all eukaryotic cells, the plasma membrane in tumor cells, and the axon in neurons. Here we show that the glycine arginine rich (GAR) domain of nucleolin drives subcellular localization via protein-protein interactions with a kinesin light chain. In addition, GAR sequences mediate plasma...
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