Implications of time-series gene expression profiles of replicative senescence.

Abstract excerpt

Although senescence has long been implicated in aging-associated pathologies, it is not clearly understood how senescent cells are linked to these diseases. To address this knowledge gap, we profiled cellular senescence phenotypes and mRNA expression patterns during replicative senescence in human diploid fibroblasts. We identified a sequential order of gain-of-senescence phenotypes: low levels of reactive oxygen...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to beta-Galactosidase
• Share to Cell Death