Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Failed Genetic Protection: Type 1 Diabetes in the Presence of HLA-DQB1*06:02.

Diabetes - 1 Aug 2020

Simmons Kimber M, Mitchell Angela M, Alkanani Aimon A, McDaniel Kristen A, Baschal Erin E, Armstrong Taylor, Pyle Laura, Yu Liping, Michels Aaron W

Abstract excerpt

Certain HLA class II genes increase the risk for type 1 diabetes (T1D) development while others provide protection from disease development. HLA class II alleles encode MHC proteins on antigen-presenting cells, which function to present peptides and activate CD4 T cells. The DRB1*15:01 (DR15)-DQA1*01:02-DQB1*06:02 (DQ6) haplotype provides dominant protection across all stages of T1D and is a common haplotype...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adolescent
Share to Alleles
Share to Child

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Child, Preschool

Share to Diabetes Mellitus, Type 1

Share to Glycated Hemoglobin

Share to Haplotypes

Share to HLA-DQ beta-Chains

Source

Open in PubMed Open full text

Identifiers

PMID: 32439825
DOI: 10.2337/db20-0038
PMCID: PMC7372070

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Failed Genetic Protection: Type 1 Diabetes in the Presence of HLA-DQB1*06:02.PMID 32439825Read ↗

Characteristics of Type 1 Diabetes Among Patients Carrying the Protective HLA-DQB1*06:02 Allele.Semantic proximity Read ↗

Increased Frequency of the HLA-DRB1*04:04-DQA1*03-DQB1*03:02 Haplotype Among HLA-DQB1*06:02-Positive Children With Type 1 Diabetes.Semantic proximity Read ↗

HLA-DRB1*15:01-DQA1*01:02-DQB1*06:02 Haplotype Protects Autoantibody-Positive Relatives From Type 1 Diabetes Throughout the Stages of Disease Progression.Semantic proximity Read ↗

DR15-DQ6 remains dominantly protective against type 1 diabetes throughout the first five decades of life.Semantic proximity Read ↗

Deciphering the Genetic Landscape: Exploring the Relationship Between HLA-DQA1, HLA-DQB1, and HLA-DRB1 Genes in Diabetes MellitusSemantic proximity Read ↗

Sequence analysis of the diabetes-protective human leukocyte antigen-DQB1*0602 allele in unaffected, islet cell antibody-positive first degree relatives and in rare patients with type 1 diabetes.Semantic proximity Read ↗

Fifty years of HLA-associated type 1 diabetes risk: history, current knowledge, and future directions.Semantic proximity Read ↗

HLA and autoimmune diseases: Type 1 diabetes (T1D) as an example.Semantic proximity Read ↗

Understanding type 1 diabetes through genetics: advances and prospects.Semantic proximity Read ↗

Functional consequences of HLA-DQ8 homozygosity versus heterozygosity for islet autoimmunity in type 1 diabetes.Semantic proximity Read ↗

Recent Expeditious Growth of Type 1 Diabetes in the Gulf Arab CountriesSemantic proximity Read ↗

Characteristics of autoantibody-positive individuals without high-risk HLA-DR4-DQ8 or HLA-DR3-DQ2 haplotypes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.