Article
Risk genes and autoantibodies in Egyptian children with type 1 diabetes - low frequency of autoantibodies in carriers of the HLA-DRB1*04:05-DQA1*03-DQB1*02 risk haplotype.
Diabetes/metabolism research and reviews - 1 Mar 2015
El-Amir Mostafa I, El-Feky Mohamed Ali, Laine Antti-Pekka, Härkönen Taina, El-Badawy Omnia, Eltayeb Azza A, El-Melegy Tarek Taha, Kiviniemi Minna, Knip Mikael, Ilonen Jorma
Abstract excerpt
BACKGROUND: The study aimed to define the frequencies of type 1 diabetes-associated gene polymorphisms and their associations with various diabetes-associated autoantibodies in Egyptian children. METHODS: One hundred and one children with type 1 diabetes and 160 healthy controls from the same region were studied for HLA-DQB1, HLA-DQA1, and HLA-DRB1 (DR4 subtypes) alleles; for INS and protein tyrosine phosphatase,...
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