Article
Monovalent IgG4 molecules: immunoglobulin Fc mutations that result in a monomeric structure.
mAbs - 1 Jan 2000
Wilkinson Ian C, Fowler Susan B, Machiesky Leeann, Miller Kenneth, Hayes David B, Adib Morshed, Her Cheng, Borrok M Jack, Tsui Ping, Burrell Matthew, Corkill Dominic J, Witt Susanne, Lowe David C, Webster Carl I
Abstract excerpt
Antibodies have become the fastest growing class of biological therapeutics, in part due to their exquisite specificity and ability to modulate protein-protein interactions with a high biological potency. The relatively large size and bivalency of antibodies, however, limits their use as therapeutics in certain circumstances. Antibody fragments, such as single-chain variable fragments and antigen...
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