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Article

Novel CH1:CL interfaces that enhance correct light chain pairing in heterodimeric bispecific antibodies.

Protein engineering, design & selection : PEDS - 1 Sept 2017

Bönisch Maximilian, Sellmann Carolin, Maresch Daniel, Halbig Claudia, Becker Stefan, Toleikis Lars, Hock Björn, Rüker Florian

Abstract excerpt

Targeting two unique antigens with a single bispecific antibody is an attractive approach with potential broad therapeutic applicability. However, the production of heterodimeric bispecific antibodies (bsAbs) presents a challenge, requiring the co-expression and accurate pairing of two distinct heavy and light chain units. Several undesirable by-products can be formed in the production process, including heavy...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28981885
DOI: 10.1093/protein/gzx044
PMCID: PMC5914326

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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