Article
Comprehensive genomic profiling reveals molecular subsets of ASXL1-mutated myeloid neoplasms.
Leukemia & lymphoma - 1 Feb 2024
Johnson Steven M, Haberberger James, Galeotti Jonathan, Ramkissoon Lori, Coombs Catherine C, Richardson Daniel R, Foster Matthew C, Duncan Daniel, Montgomery Nathan D, Ferguson Naomi L, Zeidner Joshua F
Abstract excerpt
A large-scale genomic analysis of patients with ASXL1-mutated myeloid disease has not been performed to date. We reviewed comprehensive genomic profiling results from 6043 adults to characterize clinicopathologic features and co-mutation patterns by ASXL1 mutation status. ASXL1 mutations occurred in 1414 patients (23%). Mutation co-occurrence testing revealed strong co-occurrence (p < 0.01) between mutations in...
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