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Co-occurring mutations in ASXL1, SRSF2, and SETBP1 define a subset of myelodysplastic/ myeloproliferative neoplasm with neutrophilia.

Leukemia research - 1 Aug 2023

Jain Tania, Ware Alisha D, Dalton William Brian, Pasca Sergiu, Tsai Hua-Ling, Gocke Christopher D, Gondek Lukasz P, Xian Rena R, Borowitz Michael J, Levis Mark J

Abstract excerpt

Identification of genomic signatures with consistent clinicopathological features in myelodysplastic/myeloproliferative neoplasm (MDS/MPN) is critical for improved diagnosis, elucidation of biology, inclusion in clinical trials, and development of therapies. We describe clinical and pathological features with co-existence of mutations in ASXL1 (missense or nonsense), SRSF2, and SKI homologous region of SETBP1, in...

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PMID: 37354804
DOI: 10.1016/j.leukres.2023.107345

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