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Article

Co-Mutation of ASXL1 and KRAS Defines a Novel Ultra-Adverse-Risk Subtype of Acute Myeloid Leukemia in a Large-Scale Cohort.

Cancer medicine - 1 Mar 2026

Zhao Yijing, Zhao Ting, Tang Feifei, Mo Xiaodong, Chang Yingjun, Zhao Xiaosu, Xu Lanping, Wang Yu, Zhang Xiaohui, Jiang Hao, Jiang Qian, Huang Xiaojun, Sun Yuqian

Abstract excerpt

BACKGROUND: ASXL1 mutation acute myeloid leukemia represents a clinically aggressive subtype with heterogeneous outcomes. Current evidence remains inconclusive regarding the prognostic relevance of the KRAS mutation partner in AML with ASXL1 mutation. The comprehensive mutational landscape and prognostic implications of co-occurring driver mutations remain poorly characterized. METHODS: A total of 2788...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41814508
DOI: 10.1002/cam4.71715
PMCID: PMC13093774

Genes

ASXL1
KRAS
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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Co-Mutation of ASXL1 and KRAS Defines a Novel Ultra-Adverse-Risk Subtype of Acute Myeloid Leukemia in a Large-Scale Cohort.PMID 41814508Read ↗

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