Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genomic characteristics and prognostic significance of co-mutated ASXL1/SRSF2 acute myeloid leukemia.

American journal of hematology - 1 Apr 2021

Richardson Daniel R, Swoboda David M, Moore Dominic T, Johnson Steven M, Chan Onyee, Galeotti Jonathan, Esparza Sonia, Hussaini Mohammad O, Van Deventer Hendrick, Foster Matthew C, Coombs Catherine C, Montgomery Nathan D, Sallman David A, Zeidner Joshua F

Abstract excerpt

The ASXL1 and SRSF2 mutations in AML are frequently found in patients with preexisting myeloid malignancies and are individually associated with poor outcomes. In this multi-institutional retrospective analysis, we assessed the genetic features and clinical outcomes of 43 patients with ASXL1mut SRSF2mut AML and compared outcomes to patients with either ASXL1 (n = 57) or SRSF2 (n = 70) mutations. Twenty-six (60%)...

Topics

Join the communities discussing this publication.

Cell Transformation, Neoplastic
Cocarcinogenesis
High-Throughput Nucleotide Sequencing
Kaplan-Meier Estimate

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Leukemia, Myeloid, Acute

Repressor Proteins

Serine-Arginine Splicing Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 33502020
DOI: 10.1002/ajh.26110
PMCID: PMC10284351

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genomic characteristics and prognostic significance of co-mutated ASXL1/SRSF2 acute myeloid leukemia.PMID 33502020Read ↗

Acute Myeloid Leukemia with Co‐mutated ASXL1 and SRSF2 Exhibits Monocytic Differentiation and has a Mutational Profile Overlapping with Chronic Myelomonocytic LeukemiaSemantic proximity Read ↗

Comprehensive genomic profiling reveals molecular subsets of ASXL1-mutated myeloid neoplasms.Semantic proximity Read ↗

Co-Mutation of ASXL1 and KRAS Defines a Novel Ultra-Adverse-Risk Subtype of Acute Myeloid Leukemia in a Large-Scale Cohort.Semantic proximity Read ↗

RUNX1 mutations in acute myeloid leukemia are associated with distinct clinico-pathologic and genetic features.Semantic proximity Read ↗

The characteristics and clinical prognosis analysis of ASXL1 mutations in Chinese adult patients with primary cytogenetically normal acute myeloid leukemia by next-generation sequencing.Semantic proximity Read ↗

Synergistic effect of concurrent high molecular risk mutations and lower JAK2 mutant variant allele frequencies on prognosis in patients with myelofibrosis-insights from a multicenter study.Semantic proximity Read ↗

Co-mutation of ASXL1 and SF3B1 Predicts Poorer Overall Survival Than Isolated ASXL1 or SF3B1 Mutations.Semantic proximity Read ↗

MDS/AML and AML with myelodysplasia-related gene mutations: clinical and molecular similarities.Semantic proximity Read ↗

Frequency and impact of somatic co-occurring mutations on post-transplant outcomes in acute myeloid leukemia: a multicenter registry analysis on behalf of the EBMT ALWP.Semantic proximity Read ↗

Acute myeloid leukemia ontogeny is defined by distinct somatic mutations.Semantic proximity Read ↗

Co-mutation pattern, clonal hierarchy, and clone size concur to determine disease phenotype of SRSF2P95-mutated neoplasms.Semantic proximity Read ↗

Morphologic, immunophenotypic, molecular genetic, and clinical characterization in patients with SRSF2-mutated acute myeloid leukemia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.