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Article

U2AF1 pathogenic variants in myeloid neoplasms and precursor states: distribution of co-mutations and prognostic heterogeneity.

Blood cancer journal - 21 Sept 2023

Badar Talha, Vanegas Yenny A Moreno, Nanaa Ahmad, Foran James M, Al-Kali Aref, Mangaonkar Abhishek, Murthy Hemant, Alkhateeb Hassan B, Viswanatha David, He Rong, Shah Mithun, Yi Cecilia Arana, Litzow Mark R, Gangat Naseema, Tefferi Ayalew, Patnaik Mrinal M

Abstract excerpt

We have previously recognized the genotypic and prognostic heterogeneity of U2AF1 mutations (MT) in myelofibrosis (MF) and myelodysplastic syndromes (MDS). In the current study, we considered 179 U2AF1-mutated patients with clonal cytopenia of undetermined significance (CCUS; n = 22), MDS (n = 108), MDS/acute myeloid leukemia (AML; n = 18) and AML (n = 31). U2AF1 variants included S34 (60%), Q157 (35%), and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37735430
DOI: 10.1038/s41408-023-00922-7
PMCID: PMC10514309

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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