Acute Myeloid Leukemia with Co‐mutated ASXL1 and SRSF2 Exhibits Monocytic Differentiation and has a Mutational Profile Overlapping with Chronic Myelomonocytic Leukemia

Abstract excerpt

In recent years, the genetic profile of acute myeloid leukemia (AML) has been extensively characterized, and multiple prognostically distinct subgroups have emerged. One subgroup arising in elderly patients harbors somatic mutations in RNA splicing factor genes (eg, SF3B1, SRSF2) and/or chromatin-related genes (eg, ASXL1). Mutations in these gene categories frequently co-occur in AML, in which case they result in...

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