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Article

MicroRNA-21 drives the switch to a synthetic phenotype in human saphenous vein smooth muscle cells.

IUBMB life - 1 Jul 2018

Alshanwani Aliah R, Riches-Suman Kirsten, O'Regan David J, Wood Ian C, Turner Neil A, Porter Karen E

Abstract excerpt

Cardiovascular disease is a leading cause of morbidity and mortality. Smooth muscle cells (SMC) comprising the vascular wall can switch phenotypes from contractile to synthetic, which can promote the development of aberrant remodelling and intimal hyperplasia (IH). MicroRNA-21 (miR-21) is a short, non-coding RNA that has been implicated in cardiovascular diseases including proliferative vascular disease and...

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PMID: 29659130
DOI: 10.1002/iub.1751

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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