Article
Synergistic role of protein phosphatase inhibitor 1 and sarco/endoplasmic reticulum Ca2+ -ATPase in the acquisition of the contractile phenotype of arterial smooth muscle cells.
Circulation - 18 Feb 2014
Lipskaia Larissa, Bobe Regis, Chen Jiqiu, Turnbull Irene C, Lopez Jose J, Merlet Elise, Jeong Dongtaq, Karakikes Ioannis, Ross Alexandra S, Liang Lifan, Mougenot Nathalie, Atassi Fabrice, Lompré Anne-Marie, Tarzami Sima T, Kovacic Jason C, Kranias Evangelia, Hajjar Roger J, Hadri Lahouaria
Abstract excerpt
BACKGROUND: Phenotypic modulation or switching of vascular smooth muscle cells from a contractile/quiescent to a proliferative/synthetic phenotype plays a key role in vascular proliferative disorders such as atherosclerosis and restenosis. Although several calcium handling proteins that control differentiation of smooth muscle cells have been identified, the role of protein phosphatase inhibitor 1 (I-1) in the...
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