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Article

Genetic background determines severity of Loxl1-mediated systemic and ocular elastosis in mice.

Disease models & mechanisms - 1 Nov 2023

Suarez Maria F, Schmitt Heather M, Kuhn Megan S, Watkins TeddiJo, Hake Kristyn M, Weisz Tara, Flynn Edward J, Elliott Michael H, Hauser Michael A, Stamer W Daniel

Abstract excerpt

Pseudoexfoliation syndrome (PEX) is a systemic, age-related disorder characterized by elastosis and extracellular matrix deposits. Its most significant ocular manifestation is an aggressive form of glaucoma associated with variants in the gene encoding lysyl oxidase-like 1 (LOXL1). Depending upon the population, variants in LOXL1 can impart risk or protection for PEX, suggesting the importance of genetic context....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37905384
DOI: 10.1242/dmm.050392
PMCID: PMC10668029

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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