Article
Disruption of the blood-aqueous barrier and lens abnormalities in mice lacking lysyl oxidase-like 1 (LOXL1).
Investigative ophthalmology & visual science - 10 Feb 2014
Wiggs Janey L, Pawlyk Basil, Connolly Edward, Adamian Michael, Miller Joan W, Pasquale Louis R, Haddadin Ramez I, Grosskreutz Cynthia L, Rhee Douglas J, Li Tiansen
Abstract excerpt
PURPOSE: Exfoliation syndrome (ES) is commonly associated with glaucoma, premature cataracts, and other ocular and systemic pathologies. LOXL1 gene variants are significantly associated with ES; however, the role of the protein in ES development remains unclear. The purpose of this study was to characterize the ocular phenotype in Loxl1(-/-) (null) mice. METHODS: Loxl1 null mice and strain-matched controls...
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