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Article

In Search of Mouse Models for Exfoliation Syndrome.

American journal of ophthalmology - 1 Nov 2024

Kuchtey Rachel W, Insignares Samuel, Yang Tzushan S, Kuchtey John

Abstract excerpt

PURPOSE: Exfoliation syndrome (XFS) is a systemic connective tissue disorder with elusive pathophysiology. We hypothesize that a mouse model with elastic fiber defects caused by lack of lysyl oxidase like 1 (LOXL1 encoded by Loxl1), combined with microfibril deficiency due to Fbn1 mutation (encoding fibrillin-1, Fbn1C1041G/+) will display ocular and systemic phenotypes of XFS. METHODS: Loxl1-/- was crossed with...

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Identifiers

PMID: 38909741
DOI: 10.1016/j.ajo.2024.06.015
PMCID: PMC11486597

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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