Article
Mucosal Immune Defence Gene Polymorphisms as Relevant Players in the Pathogenesis of IgA Vasculitis?
International journal of molecular sciences - 22 Aug 2023
Batista-Liz Joao Carlos, Calvo-Río Vanesa, Sebastián Mora-Gil María, Sevilla-Pérez Belén, Márquez Ana, Leonardo María Teresa, Peñalba Ana, Carmona Francisco David, Narvaez Javier, Martín-Penagos Luis, Belmar-Vega Lara, Gómez-Fernández Cristina, Caminal-Montero Luis, Collado Paz, Quiroga-Colina Patricia, Uriarte-Ecenarro Miren, Rubio Esteban, Luque Manuel León, Blanco-Madrigal Juan María, Galíndez-Agirregoikoa Eva, Martín Javier, Castañeda Santos, González-Gay Miguel Angel, Blanco Ricardo, Pulito-Cueto Verónica, López-Mejías Raquel
Abstract excerpt
ITGAM-ITGAX (rs11150612, rs11574637), VAV3 rs17019602, CARD9 rs4077515, DEFA (rs2738048, ), and HORMAD2 are mucosal immune defence polymorphisms, that have an impact on IgA production, described as risk loci for IgA nephropathy (IgAN). Since IgAN and Immunoglobulin-A vasculitis (IgAV) share molecular mechanisms, with the aberrant deposit of IgA1 being the main pathophysiologic feature of both...