Clinical and Genetic Spectrum of a Large Cohort With Total and Sub-total Complement Deficiencies

doi:10.3389/fimmu.2019.01936

Article

Clinical and Genetic Spectrum of a Large Cohort With Total and Sub-total Complement Deficiencies

8 Aug 2019

Abstract excerpt

The complement system is crucial for defense against pathogens and removal of dying cells or immune complexes. Thus, clinical indications for possible complete complement deficiencies include among others recurrent mild or serious bacterial infections as well as autoimmune diseases. The diagnostic approach includes functional activity measurements of the classical (CH50) and alternative pathway (AP50) and the...

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