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Low C4A copy numbers and higher HERV gene insertion contributes to increased risk of SLE, with absence of association with disease phenotype and disease activity.

Immunologic research - 1 Aug 2024

Mariaselvam Christina Mary, Seth Gaurav, Kavadichanda Chengappa, Boukouaci Wahid, Wu Ching-Lien, Costes Bruno, Thabah Molly Mary, Krishnamoorthy Rajagopal, Leboyer Marion, Negi Vir Singh, Tamouza Ryad

Abstract excerpt

Low copy numbers (CNs) of C4 genes are associated with systemic autoimmune disorders and affects autoantibody diversity and disease subgroups. The primary objective of this study was to characterize diversity of complement (C4) and C4-Human Endogenous Retrovirus (HERV) gene copy numbers in SLE. We also sought to assess the association of C4 and C4-HERV CNs with serum complement levels, autoantibodies, disease...

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Source

Identifiers

PMID: 38594415
DOI: 10.1007/s12026-024-09475-8

Genes

C4A
C4B

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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