Article
The association of MTHFR C677T variant with increased risk of ischemic stroke in the elderly population: a meta-analysis of observational studies.
BMC geriatrics - 27 Nov 2019
Chang Guilin, Kuai Zheng, Wang Jia, Wu Jiayu, Xu Kan, Yuan Ying, Hu Yu
Abstract excerpt
BACKGROUND: C677T point mutation in methylenetetrahydrofolate reductase (MTHFR) gene have been found to be associated with ischemic stroke in general population, while the results seem inconsistent. We aim to assess the association between variant MTHFR C677T variant and increased risk of ischemic stroke and focus on the elderly population. METHODS: We searched PubMed, Embase, Cochrane Library, and Web of Science...
Topics
- Aged
- Alleles
- Brain Ischemia
- Genetic Predisposition to Disease
- Humans
- Methylenetetrahydrofolate Reductase (NADPH2)
- Observational Studies as Topic
- Odds Ratio
- Risk Factors
- Stroke