MTHFR C677T mutation increased the risk of Ischemic Stroke, especially in large-artery atherosclerosis in adults: an updated meta-analysis from 38 researches.

Abstract excerpt

BACKGROUND: To date, many publications have evaluated the correlation between the Ethylenetetrahydrofolate reductase gene (MTHFR) C677T and Ischemic Stroke susceptibility in adults. However, the results remain inconclusive. The meta-analysis was performed to resolve the problem. METHODS: Based on 38 studies, dichotomous data were presented as the odds ratio (OR) with a 95% confidence interval (CI). RESULTS: This...

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