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Article

CRISPR-Cas9-mediated generation of obese and diabetic mouse models.

Experimental animals - 10 May 2018

Roh Jae-Il, Lee Junghoon, Park Seong Uk, Kang Young-Shin, Lee Jaehoon, Oh Ah-Reum, Choi Dong Joon, Cha Ji-Young, Lee Han-Woong

Abstract excerpt

Mouse models of obesity (ob/ob) and diabetes (db/db) in which the leptin (Lep) and leptin receptor (Lepr) genes have been mutated, respectively, have contributed to a better understanding of human obesity and type 2 diabetes and to the prevention, diagnosis, and treatment of these metabolic diseases. In this study, we report the first CRISPR-Cas9-induced Lep and Lepr knockout (KO) mouse models by...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29343656
DOI: 10.1538/expanim.17-0123
PMCID: PMC5955754

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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