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Article

Tissue inhibitor of metalloproteinase 3 deficiency causes hepatic steatosis and adipose tissue inflammation in mice.

Gastroenterology - 1 Feb 2009

Menghini Rossella, Menini Stefano, Amoruso Roberta, Fiorentino Loredana, Casagrande Viviana, Marzano Valeria, Tornei Federica, Bertucci Pierfrancesco, Iacobini Carla, Serino Matteo, Porzio Ottavia, Hribal Marta L, Folli Franco, Khokha Rama, Urbani Andrea, Lauro Renato, Pugliese Giuseppe, Federici Massimo

Abstract excerpt

BACKGROUND & AIMS: Obesity-driven, low-grade inflammation affects systemic metabolic function and can lead to insulin resistance, hepatic steatosis, and atherosclerosis. Decreased expression of tissue inhibitor of metalloproteinase 3 (Timp3) is a catalyst for insulin resistance and inflammation. Timp3 is a natural inhibitor of matrix metalloproteinases, tumor necrosis factor-alpha-converting enzyme (TACE), and...

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PMID: 19027012
DOI: 10.1053/j.gastro.2008.10.079

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