Article
Changes in environmental stress over COVID-19 pandemic likely contributed to failure to replicate adiposity phenotype associated with Krtcap3.
Physiological genomics - 1 Oct 2023
Szalanczy Alexandria M, Giorgio Gina, Goff Emily, Seshie Osborne, Grzybowski Michael, Klotz Jason, Geurts Aron M, Redei Eva E, Solberg Woods Leah C
Abstract excerpt
We previously identified keratinocyte-associated protein 3, Krtcap3, as an obesity-related gene in female rats where a whole body Krtcap3 knockout (KO) led to increased adiposity compared to wild-type (WT) controls when fed a high-fat diet (HFD). We sought to replicate this work to better understand the function of Krtcap3 but were unable to reproduce the adiposity phenotype. In the current work, WT female rats...
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