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Article

LSM14B is essential for oocyte meiotic maturation by regulating maternal mRNA storage and clearance

27 Oct 2023

Abstract excerpt

Fully grown oocytes remain transcriptionally quiescent, yet many maternal mRNAs are synthesized and retained in growing oocytes. We now know that maternal mRNAs are stored in a structure called the mitochondria-associated ribonucleoprotein domain (MARDO). However, the components and functions of MARDO remain elusive. Here, we found that LSM14B knockout prevents the proper storage and timely clearance of mRNAs...

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PMID: 37889087
DOI: 10.1093/nar/gkad919

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