Tumor microenvironment-induced tumor cell plasticity: relationship with hypoxic stress and impact on tumor resistance

Abstract excerpt

The role of tumor interaction with stromal components during carcinogenesis is crucial for the design of efficient cancer treatment approaches. It is widely admitted that tumor hypoxic stress is associated with tumor aggressiveness and thus impacts susceptibility and resistance to different types of treatments. Notable biological processes that hypoxia functions in include its regulation of tumor heterogeneity...

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