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Article

Impact of the hypoxic tumor microenvironment on the regulation of cancer stem cell characteristics

15 Jun 2010

Abstract excerpt

Solid tumors often contain regions with insufficient oxygen delivery, a condition called hypoxia. Tumor hypoxia is an independent prognostic factor significantly correlated with advanced stages of malignancy, increased resistance to conventional therapy, and reduced disease-free survival. Hypoxic tumor cells exhibit poorly differentiated phenotypes resembling stem or progenitor cells. Studies have shown that...

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PMID: 20581454
DOI: 10.4161/cbt.9.12.12347

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