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Article

The hypoxic microenvironment maintains glioblastoma stem cells and promotes reprogramming towards a cancer stem cell phenotype.

Cell cycle (Georgetown, Tex.) - 15 Oct 2009

Heddleston John M, Li Zhizhong, McLendon Roger E, Hjelmeland Anita B, Rich Jeremy N

Abstract excerpt

Glioblastomas are highly lethal cancers that contain cellular hierarchies with self-renewing cancer stem cells that can propagate tumors in secondary transplant assays. The potential significance of cancer stem cells in cancer biology has been demonstrated by studies showing contributions to therapeutic resistance, angiogenesis and tumor dispersal. We recently reported that physiologic oxygen levels...

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Identifiers

PMID: 19770585
DOI: 10.4161/cc.8.20.9701
PMCID: PMC2825672

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MYC
NANOG

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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