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Article

Hypoxia in the glioblastoma microenvironment: shaping the phenotype of cancer stem-like cells.

Neuro-oncology - 1 Jul 2017

Colwell Nicole, Larion Mioara, Giles Amber J, Seldomridge Ashlee N, Sizdahkhani Saman, Gilbert Mark R, Park Deric M

Abstract excerpt

Glioblastoma is the most common and aggressive malignant primary brain tumor. Cellular heterogeneity is a characteristic feature of the disease and contributes to the difficulty in formulating effective therapies. Glioma stem-like cells (GSCs) have been identified as a subpopulation of tumor cells that are thought to be largely responsible for resistance to treatment. Intratumoral hypoxia contributes to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28339582
DOI: 10.1093/neuonc/now258
PMCID: PMC5570138

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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