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Article

Role of hypoxia inducible factor-1 in cancer stem cells (Review)

3 Nov 2020

Abstract excerpt

Cancer stem cells (CSCs) have been found to play a decisive role in cancer recurrence, metastasis, and chemo‑, radio‑ and immuno‑resistance. Understanding the mechanism of CSC self‑renewal and proliferation may help overcome the limitations of clinical treatment. The microenvironment of tumor growth consists of a lack of oxygen, and hypoxia has been confirmed to induce cancer cell invasion, metastasis and...

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PMID: 33179080
DOI: 10.3892/mmr.2020.11655

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