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Cancer stem-like cells stay in a plastic state ready for tumor evolution

6 Feb 2025

Abstract excerpt

• The plasticity of CSCs results in intratumor heterogeneity in solid tumors. • CSCs play a central role in the development of adaptive therapeutic resistance. • CSC markers and intrinsic signaling pathways inspire CSC-targeted therapies. • Unique CSC microenvironment provides valuable insights for CSC-targeted therapies. Cell plasticity emerges as a novel cancer hallmark and is pivotal in driving tumor...

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PMID: 39919692
DOI: 10.1016/j.neo.2025.101134

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