Article
Regularized multi-trait multi-locus linear mixed models for genome-wide association studies and genomic selection in crops.
BMC bioinformatics - 26 Oct 2023
Lozano Aurélie C, Ding Hantian, Abe Naoki, Lipka Alexander E
Abstract excerpt
BACKGROUND: We consider two key problems in genomics involving multiple traits: multi-trait genome wide association studies (GWAS), where the goal is to detect genetic variants associated with the traits; and multi-trait genomic selection (GS), where the emphasis is on accurately predicting trait values. Multi-trait linear mixed models build on the linear mixed model to jointly model multiple traits. Existing...
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