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Hybrid of Restricted and Penalized Maximum Likelihood Method for Efficient Genome-Wide Association Study.

Genes - 29 Oct 2020

Ren Wenlong, Liang Zhikai, He Shu, Xiao Jing

Abstract excerpt

In genome-wide association studies, linear mixed models (LMMs) have been widely used to explore the molecular mechanism of complex traits. However, typical association approaches suffer from several important drawbacks: estimation of variance components in LMMs with large scale individuals is computationally slow; single-locus model is unsatisfactory to handle complex confounding and causes loss of statistical...

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PMID: 33138126
DOI: 10.3390/genes11111286
PMCID: PMC7692801

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