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Article

Multi-population GWA mapping via multi-task regularized regression.

Bioinformatics (Oxford, England) - 15 Jun 2010

Puniyani Kriti, Kim Seyoung, Xing Eric P

Abstract excerpt

MOTIVATION: Population heterogeneity through admixing of different founder populations can produce spurious associations in genome-wide association studies that are linked to the population structure rather than the phenotype. Since samples from the same population generally co-evolve, different populations may or may not share the same genetic underpinnings for the seemingly common phenotype. Our goal is to...

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PMID: 20529908
DOI: 10.1093/bioinformatics/btq191
PMCID: PMC2881376

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