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Article

Low Input Whole-Exome Sequencing to Determine the Representation of the Tumor Exome in Circulating DNA of Non-Small Cell Lung Cancer Patients.

PloS one - 1 Jan 2016

Dietz Steffen, Schirmer Uwe, Mercé Clémentine, von Bubnoff Nikolas, Dahl Edgar, Meister Michael, Muley Thomas, Thomas Michael, Sültmann Holger

Abstract excerpt

Circulating cell-free DNA (cfDNA) released from cancerous tissues has been found to harbor tumor-associated alterations and to represent the molecular composition of the tumor. Recent advances in technologies, especially in next-generation sequencing, enable the analysis of low amounts of cfDNA from body fluids. We analyzed the exomes of tumor tissue and matched serum samples to investigate the molecular...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27529345
DOI: 10.1371/journal.pone.0161012
PMCID: PMC4987014

Genes

ALK
MTOR
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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