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Article

Correlation of Somatic Genomic Alterations Between Tissue Genomics and ctDNA Employing Next-Generation Sequencing: Analysis of Lung and Gastrointestinal Cancers.

Molecular cancer therapeutics - 1 May 2018

Toor Omer M, Ahmed Zaheer, Bahaj Waled, Boda Urooge, Cummings Lee S, McNally Megan E, Kennedy Kevin F, Pluard Timothy J, Hussain Arif, Subramanian Janakiraman, Masood Ashiq

Abstract excerpt

Next-generation Sequencing (NGS) of cancer tissues is increasingly being carried out to identify somatic genomic alterations that may guide physicians to make therapeutic decisions. However, a single tissue biopsy may not reflect complete genomic architecture due to the heterogeneous nature of tumors. Circulating tumor DNA (ctDNA) analysis is a robust noninvasive method to detect and monitor genomic alterations...

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Identifiers

PMID: 29500272
DOI: 10.1158/1535-7163.MCT-17-1015

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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